Transfusion support of thrombotic thrombocytopenic purpura ttp. How is post transfusion purpura potentially lethal complication of blood transfusion abbreviated. Blood transfusion guideline international society of blood. These guidelines have been developed in conjunction with the hospital transfusion committee. Pdf posttransfusion purpura is a rare syndrome characterized by severe thrombocytopenia and bleeding caused by alloimunization to. Post transfusion purpura ptp is a rare but well defined syndrome first characterized by shulman et al. A posttransfusion platelet count should be obtained 10 minutes to 1 hour after transfusion for best assessment of transfusion effectiveness. Posttransfusion purpura ptp is a rare and potentially fatal transfusion reaction leading to severe thrombocytopenia occurring approximately 1 week after blood transfusions. Chapel hill, nc pediatrics the following criteria represent institution consensus indications for the transfusion of blood and. Transfusion medicine posttransfusion purpura ptp assessment. We would like to show you a description here but the site wont allow us. Transfusion medicine a nonimmune response to transfusion of packed rbcs and ffp, attributed to passive transfer of antibodies from donor plasma, resulting in. Transfusion support of thrombotic thrombocytopenic purpura ttp nicholas bandarenko, md, fcap director, transfusion services duke university.
Platelet transfusion and thrombotic thrombocytopenic purpura. Specialist working group for haematology proposed changes to the criteria for the clinical use of intravenous immunoglobulin in australia, second edition. Post transfusion purpura is a rare immunohematological disorder characterized by severe thrombocytopenia following transfusion of blood components and induced by an alloantibody against a donor platelet antigen. Congenital ttp is a rare autosomal recessive disease present in childhood. Posttransfusion definition of posttransfusion by medical. Posttransfusion purpura ptp can occur in patients who have been previously sensitized to platelets by transfusion or through pregnancy. Acquired ttp is mainly idiopathic, but there are other conditions and comorbidities besides idiopathic. As a result, transfusion carries risks of immunologic reactions. Posttransfusion purpura ptp is a delayed adverse reaction to a blood transfusion or platelet transfusion that occurs when the body has produced alloantibodies to the allogeneic. Posttransfusion purpura ptp is a rare disorder with a historical incidence estimated to be between 1 in 25,000. Pathophysiology, treatment, and prevention of post. Post transfusion purpura ptp post transfusion purpura ptp specialty haematology haematology chapter 6 6 specific conditions level of. Acquired ttp is mainly idiopathic, but there are other conditions and. Posttransfusion purpura is a complication of blood product transfusion in which the recipient produces.
The uab coagulation service is dedicated to meeting the coagulation medicine needs of the southeast. Transfusion support of thrombotic thrombocytopenic. Prior exposure to foreign platelet antigens, through transfusion, transplant or pregnancy can result in antihuman platelet antigen antibodies. Post transfusion purpura ptp can occur in patients who have been previously sensitized to platelets by transfusion or through pregnancy. Post transfusion purpura is a rare syndrome characterized by severe thrombocytopenia and bleeding caused by alloimunization to human platelet specific antigens following a blood component transfusion. Lehigh valley health network lvhn scholarly works department of medicine post transfusion purpura. What is the abbreviation for posttransfusion purpura. Post transfusion purpura ptp is an uncommonly reported post transfusion adverse event that can present with severe thrombocytopenia. Post transfusion purpura ptp is an uncommon but serious transfusion associated complication characterized by profound thrombocytopenia. Pathophysiology, treatment, and prevention of posttransfusion purpura ptp ptp is caused by plateletspecific antibodies in a patient who has been previously exposed to platelet antigens through pregnancy or transfusion. If transfused in an at risk country and a validated malarial antibody test andor as appropriate a validated test for t. Lehigh valley health network lvhn scholarly works department of medicine posttransfusion purpura. Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Posttransfusion purpura is a rare immunohematological disorder characterized by severe thrombocytopenia following transfusion of blood components and induced by an.
Thank you to ashley, for presenting the case of a middleaged woman who developed severe, postoperative thrombocytopenia. Posttransfusion purpura ptp, first described in the late 1950s, 2,151,152 is a rare but serious complication of blood transfusion. Transfusion medicine a nonimmune response to transfusion of packed rbcs and ffp, attributed to passive transfer of antibodies from donor plasma, resulting in complement activation and lung injury clinical bilateral pulmonary edema, hypoxia, tachycardia, fever and hypotension occurring within 6 hrs of transfusion. Thrombotic thrombocytopenia ttp is a life threatening disorder characterized by clotting in small blood vessels resulting in reduced blood supply to end organs such as the central. We report two cases of ptp and discuss the clinical presentation, diagnosis and management of this. It is characterized by the sudden onset of thrombocytopenia with purpura in the 710 days following a blood transfusion. Posttransfusion purpura ucsf internal medicine chief. Logdberg, in blood banking and transfusion medicine second edition, 2007. University of michigan hospitals and health centers adult blood transfusion clinical guidelines. Learning objectives understand the ttp syndrome and its relevance to blood banking be familiar with the pathogenesis and laboratory diagnosis of ttp explain how therapeutic apheresis is. Post transfusion purpura ptp is a rare and potentially fatal transfusion reaction leading to severe thrombocytopenia occurring approximately 1 week after blood transfusions. May 24, 20 posttransfusion purpura ptp is a rare and potentially fatal transfusion reaction leading to severe thrombocytopenia occurring approximately 1 week after blood transfusions. Although this is rare and less common in males, it can occur, particularly as a patients comorbidities increased.
Ptp is characterized by the development of severe, sudden and selflimiting thrombocytopenia occurring 510 days after a blood transfusion. Thrombocytopenia nat, posttransfusion purpura ptp and platelet transfusion refractoriness are associated with the development of plateletspecific antibodies. Jun 01, 2003 read platelet transfusion and thrombotic thrombocytopenic purpura, transfusion on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Apr 28, 2017 posttransfusion purpura ptp what is it. Preoperative anaemia identification, assessment and management case study. The official publication for icd9cm and icd10cmpcs. Posttransfusion purpura in an africanamerican man due to. Blood transfusion clinical guideline michigan medicine. Posttransfusion purpura ptp pdf national blood authority. This is characterised by the development of severe thrombocytopenia approximately a week after blood transfusion. Post transfusion purpura is an acute episode of severe thrombocytopenia occurring 58 days after blood transfusion in a patient with a history of sensitization by pregnancy or transfusion.
Posttransfusion purpura an overview sciencedirect topics. It is caused by alloimmunization against platelet antigens, antihpa1a being the most frequent antibody. Jane doe is a 63 year old woman who presented 11 days after prbc transfusion with severe. Posttransfusion purpura ptp australian red cross lifeblood. Posttransfusion purpura ptp is a rare bleeding disorder caused by alloantibodies specific to platelet antigens. Aabb guideline for platelet transfusions the aabb, formerly the american association of blood banks, has developed a guideline on appropriate use of platelet transfusion in adult patients. Oct 23, 2012 post transfusion purpura, ptp ptp is a rare 1 50000 but severe side effect of blood transfusion that resembles dtr due to red cell transfusion in more than 90% of patients ptp is encountered in women who are hpa1b and have developed anti hpa1a antibodies due to immunization by previous pregnancy fall in platelet count 5 to 10 days. Ptp abbreviation stands for post transfusion purpura. The recipients always have a history of sensitization. The thrombocytopenic episode lasted for 22 and over 60 days. Posttransfusion definition of posttransfusion by merriam. Posttransfusion purpura article about posttransfusion. Home posttransfusion purpura ptp pdf posttransfusion purpura ptp pdf file.
Posttransfusion purpura ptp is a rare complication of transfusion that most commonly occurs in. Clinical outcomes after platelet transfusions in patients. What is the abbreviation for post transfusion purpura. Post transfusion purpura ptp submitted by admin on wed, 20100310 12. Posttransfusion purpura is an immune mediated transfusion reaction with a low incidence in transfusion recipients. Posttransfusion definition is caused by transfused blood.
Posttransfusion purpura ptp is a rare yet serious disease characterized by severe thrombocytopenia occurring after a blood transfusion. Purpura thrombotque thrombocytopenique et grossesse marih. Ptp is caused by alloimmunization to human platelet specific antigens following blood component transfusion. Diagnosis and management of posttransfusion purpura. Ptp is defined as post transfusion purpura potentially. Post transfusion purpura this test is referred to another lab outside our network this does not affect where samples are sent and where your results are issued. Post transfusion purpura ptp workup bloodworks northwest. Platelet destruction occurs when immune reactions of uncertain type, involving high titre platelet antibodies, somehow destroy transfused platelets and the patients own platelets.
Ptp is defined as post transfusion purpura potentially lethal complication of blood transfusion frequently. Post transfusion purpura, ptp ptp is a rare 1 50000 but severe side effect of blood transfusion that resembles dtr due to red cell transfusion in more than 90% of patients. Post transfusion purpura ptp aha coding clinic icd9cm. In one case, thrombocytopenia was associated with agranulocytosis due to. May 23, 20 posttransfusion purpura ptp is an uncommon, but potentially fatal, transfusion reaction characterized by profound thrombocytopenia and bleeding. Transfusion of cellular blood products containing any platelets e. It is the goal of the university of michigan health system to provide. The purpura was evoked by blood transfusions with a latent period of 2 and 7 days.
Posttransfusion purpura ptp is a rare and delayed transfusion reaction that typically occurs in multiparous women. Thrombocytopenia occurs approximately one week after the administration of blood,1, 2 a. Posttransfusion purpura ptp, first described in the late 1950s, 2,151,152 is a rare but serious. Current guidelines advise against the transfusion of platelets in patients with thrombotic thrombocytopenic purpura ttp except in cases of lifethreatening hemorrhage. Guidelines for the transfusion of blood components introduction. These antibodies cause destruction of the transfused platelets as well. Posttransfusion purpura is a complication of blood product transfusion in which the recipient produces antiplatelet antibodies resulting in severe thrombocytopenia. Management of platelet disorders coagulation service. Posttransfusion purpura ptp is a rare complication of transfusion resulting in.
Post transfusion purpura is an acute, severe, thrombocytopenic state that has been described in 15 patients. Scully m, hunt bj, benjamin s, liesner r, rose p, peyvandi f, et al. Posttransfusion p, bp and t not more than 60 minutes after. Posttransfusion purpura ptp pdf posttransfusion purpura ptp pdf file. Posttransfusion purpura ptp is a delayed adverse reaction to a blood transfusion or platelet. Thrombotic thrombocytopenic purpura ttp is categorized into acquired idiopathic ttp and congenital familial ttp. We unify the collective knowledge of pathology, internal medicine, hematology. The following cases of posttransfusion purpura were. Transfusion practice clinical outcomes after platelet transfusions in patients with thrombotic thrombocytopenic purpura karen k. Posttransfusion purpura ptp is an uncommon, but potentially fatal, transfusion reaction characterized by profound thrombocytopenia and bleeding. Joint united kingdom uk blood transfusion and tissue transplantation services professional advisory committee. The following cases of posttransfusion purpura were studied. Posttransfusion purpura occurs when a person with an antiplatelet antibody is transfused with platelets expressing the corresponding antigen.
Read platelet transfusion and thrombotic thrombocytopenic purpura, transfusion on deepdyve, the largest online rental service for scholarly research with thousands of. Post transfusion purpura ptp subscription required. Two patients with post transfusion thrombocytopenic purpura are described, the first cases recognized in austria and germany. Ptp stands for post transfusion purpura potentially lethal complication of blood transfusion. Bleeding from mucous membranes and the gastrointestinal and urinary tracts is common.
Immunological complications of blood transfusion medscape. Posttransfusion purpura successful treatment by exchange. Post transfusion purpura is a complication of blood product transfusion in which the recipient produces antiplatelet antibodies resulting in severe thrombocytopenia. Le diagnostic biologique combine des techniques serologiques. Ptp abbreviation stands for posttransfusion purpura.
Posttransfusion purpura ptp is a rare but well defined syndrome first characterized by shulman et al. Cushing md, in transfusion medicine and hemostasis second edition, 20. Posttransfusion purpura definition of posttransfusion. Laboratory testing for immunemediated platelet transfusion refractoriness.
Its incidence is approximately 1 in 50 000100 000 blood transfusions and occurs more commonly in multiparous women. Posttransfusion purpura is an acute episode of severe thrombocytopenia occurring 58 days after blood transfusion in a patient with a history of sensitization by pregnancy or transfusion. These alloantibodies destroy the patients platelets leading to thrombocytopenia, a rapid decline in platelet count. The typical patient is a multiparous woman who develops sudden severe purpura 1 week after receiving a transfusion of packed red cells or whole blood. Chapel hill, nc pediatrics the following criteria represent institution consensus indications for the transfusion of blood and blood components. Posttransfusion purpura ptp is a rare disorder with a historical incidence estimated to be between 1 in 25,000 to. An extremely rare transfusion reaction only 250 cases reported. The page below is a sample from the labce course transfusion reactions. Two patients with posttransfusion thrombocytopenic purpura are described, the first cases recognized in austria and germany. The antibody against the human platelet alloantigen hpa1a is responsible for. Thrombocytopenia occurs approximately one week after the. Occurring after or as a consequence of blood transfusion. Pathophysiology, treatment, and prevention of posttransfusion purpura ptp ptp is caused by plateletspecific antibodies in a patient who has been previously exposed to platelet antigens.
It occurs primarily in women sensitized by pregnancy and is most commonly caused by antihuman platelet antigen1a antibodies. Posttransfusion purpura is an acute, severe, thrombocytopenic state that has been described in 15 patients. Ptp is a rare delayed transfusion reaction where a patient develops dramatic, sudden and selflimiting thrombocytopenia platelet counts transfusion. As well as the printed edition, the handbook will also be published in pdf and web. Reports of deterioration and death after platelet plt transfusions in patients with throm. Although there is evidence of a wide serological spectrum of culprit antibodies implicated, antihumanplateletantigen hpa 1a is the.